Regulation of bacterial virulence

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Virulence is regulated by intricate regulatory circuits. We are investigating virulence regulation using enteropathogenic E. coli (EPEC) as a central model. This includes study of both transcriptional and posttranscriptional regulation. We recently found that the injectisome (T3SS) serve as a sensing device that couples between virulence regulation, injectisome activity, metabolic regulation and adaptation of the pathogen to  a host-attached lifestyle.

 

1. Yerushalmi G., Gur-Arie L., Litvak Y., and Rosenshine I. (2014) Dynamics of expression and maturation of the type III secretion system of enteropathogenic Escherichia coli. J. Bacteriol. 196:2798-2806.

2. Padavannil A., Jobichen C., Mills E., Velazquez-CampoyA., Li MoL., Leung KY., Mok YK., Rosenshine I., Sivaraman J. Structure of GrlR-GrlA complex that prevents GrlA activation of virulence genes (2013), Nature communication. 4:2546 

3. Ronin I., Katsowich N., Rosenshine I., and Balaban N., (2017) A Long-term Epigenetic Memory Switch Controls Bacterial Virulence Bimodality. eLife, e19599. doi: 10.7554/eLife.19599 (corresponding author)

4. Naama Katsowich, Netanel Elbaz, Ritesh Ranjan Pal, Erez Mills, Simi Kobi, Tamar Kahan and Ilan Rosenshine (2017) Host-cell attachment elicits post-transcriptional regulation in infecting enteropathogenic bacteria. Science, 355(6326):735-739

5. Elbaz N., Socol Y., Katsowich N. and I Rosenshine. Control of type III secretion system effector/chaperone ratio fosters pathogen adaptation to host adherent lifestyle. (2019), mBio, e02074-19. doi: 10.1128/mBio.02074-19

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